SCN9A
The gene SCN9A is responsible for human pain disorders. Nonsense (single base) mutations can
cause a complete absence of pain. Thanks to two Mendelian mutations in exons 15 and 16,
people lose the perception of pain. We are developing a new
approach during treatments without medical drugs such as NSAIDs, Opioid drugs,
Glucocorticoids, and Local anaesthesia.
Our approach focuses on editing the genome to minimise side effects during health
treatments compared to other drugs. Our procedure aims to make patients temporally lose pain
perception to heal faster and with a higher standard of life. Indeed,
patients can be more optimistic without the perception of pain, reducing physiological
stress factors that can influence her healing condition.
